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Disrupting the p53-FOXO4 interaction causes p53 to be excluded from the nucleus and directed to mitochondria for induction of apoptosis in senescent cells, ultimately eliminating senescent fibroblasts through triggering apoptosis (Baar et al., 2017)

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The 13.7% weight loss in patients with type 2 diabetes follows the established pattern: patients with diabetes consistently lose less weight on anti-obesity drugs than patients without diabetes